Mayo Clinic Platform Digital Health & Startup Portfolio — page 1

E X E C U T I V E P O R T F O L I O 2 0 2 6

Mayo Clinic Platform

Digital Health &

Startup Portfolio

Clinical Data • Artificial Intelligence • Digital Health Innovation • Startup

Acceleration • Enterprise Healthcare Ecosystem

Mayo Clinic Platform Digital Health & Startup Portfolio — page 2

E N T E R P R I S E E C O S Y S T E M

Mayo Clinic Platform Architecture

Mayo Clinic Platform serves as the nexus for global healthcare transformation, providing the

infrastructure and ethical framework necessary to turn vast clinical datasets into actionable

insights. By creating a federated architecture that bridges clinical expertise with cloud-scale

computational power, we enable a global network of innovation.

PLATFORM INTERACTION LAYER

External Partners

Microsoft, GE HealthCare, Life Sciences

Innovation Hub

Startups, Researchers, Academics

Mayo Clinic Platform Core

Unified Data Fabric • De-identification Engine • Governance Framework

Clinical Source

Mayo Clinic EHR

Network Source

Global Member Systems

Our secure clinical data infrastructure is

designed for the modern era of medicine.

Utilizing advanced de-identification protocols,

the platform allows for the training of complex

AI models without ever compromising the

sanctity of the patient-physician relationship.

This "Privacy-by-Design" approach is the

cornerstone of our global collaboration

framework, allowing diverse healthcare

organizations to contribute data to a collective

intelligence that benefits all patients.

Mayo Clinic Platform Digital Health & Startup Portfolio — page 3

I N T E L L I G E N C E P O R T F O L I O

Digital Health Data & AI Solutions

Transforming raw clinical data into digital health solutions requires a specialized suite of tools.

Mayo Clinic Platform provides the essential bridge between the laboratory and the bedside

through three core functional pillars.

Platform_Insights

An advanced analytical discovery engine. Insights

allows researchers to query de-identified

longitudinal records to uncover disease patterns and

treatment efficacy across vast populations.

Platform_Orchestrate

The deployment backbone. Orchestrate ensures that

validated AI models are seamlessly integrated into

the clinician's workflow, appearing precisely when

and where they are needed.

Platform_Solutions Studio

The development sandbox. Solutions Studio provides

a high-fidelity environment for AI developers to

build, test, and refine models against real-world

clinical context and constraints.

Predictive Analytics

Moving from reactive to proactive care. Our AI

portfolio includes risk-stratification models for

cardiology, oncology, and acute care management

using de-identified real-world evidence.

Data Modalities & Harmonization

We specialize in the harmonization of multi-modal data streams, including high-resolution medical

imaging (DICOM), genomics, electronic health records (EHR), and real-world evidence. This multi-

dimensional view enables the next generation of precision medicine.

Mayo Clinic Platform Digital Health & Startup Portfolio — page 4

I N N OVAT I O N AC C E L E R AT I O N

Mayo Clinic Platform_Accelerate

The Accelerate program is an institutional commitment to the future of healthcare. It is not

merely an incubator; it is a clinical validation engine that provides the world's most promising

startups with the data, expertise, and environment needed to scale.

Accelerate Portfolio 2025-2026

Bloom Standard:

Revolutionizing pediatric cardiac

screening via AI-driven autonomous ultrasound.

Voythos:

Automating EHR documentation through

intelligent clinical voice synthesis.

Burna AI:

Precision assessment and management

protocols for complex thermal injuries.

Aquoris Intelligence:

Streamlining cross-

institutional data interoperability for clinical trials.

Cardiolife:

Predictive arrhythmia detection using

wearable sensor fusion.

Program Framework

30-Week Immersive Path

Intensive clinical and business validation phases.

Physician Collaboration

Direct access to Mayo Clinic subject matter experts

for product refinement.

Regulatory Readiness

Assistance in navigating FDA and international

compliance pathways.

•

Mayo Clinic Platform Digital Health & Startup Portfolio — page 5

G L O B A L A L L I A N C E S

Enterprise Partnerships & Alliances

Scale is achieved through strategic

collaboration. Mayo Clinic Platform acts as the

central hub for a diverse ecosystem of

enterprise partners—from cloud infrastructure

giants to pharmaceutical innovators—all

working toward the common goal of healthcare

transformation.

Our partnership with

Microsoft

leverages

Azure's global scale and security to host the

Platform’s core data services. Collaboration

with

GE HealthCare

focuses on integrating

advanced imaging algorithms into clinical

equipment. Meanwhile, our work with life

sciences leaders accelerates drug discovery

through high-fidelity real-world evidence and

synthetic control arms for clinical trials.

PARTNERSHIP ECOSYSTEM VISION

CLOUD &

INFRASTRUCTURE

Scalability & Security

LIFE SCIENCES

Discovery &

Evidence

MEDICAL

TECHNOLOGY

Hardware-AI

Integration

GLOBAL HEALTH

SYSTEMS

Collaborative Networks

Mayo Clinic Platform Digital Health & Startup Portfolio — page 6

E X E C U T I V E S U M M A R Y

Portfolio Summary & Strategic Impact

Mayo Clinic Platform has evolved from a repository of world-class expertise into a dynamic engine for

digital health delivery. Our portfolio represents the integration of data, artificial intelligence, and

startup ingenuity into a single, unified ecosystem.

PORTFOLIO

DIVISION

CORE CAPABILITIES

PRIMARY USERS

HEALTHCARE VALUE

Data & Insights

RWE Discovery, EHR

Analysis

Life Sciences,

Academics

Accelerated Evidence

Generation

Accelerate

Startup Sandbox,

Validation

Early-stage

Innovators

Validated Market Entry

Orchestrate

Clinical AI Deployment

Physicians, Nurses

Point-of-care Intelligence

Solutions Studio

AI Testing,

Benchmarking

Model Developers

Safe & Effective Model

Scaling

Closing Executive Perspective

The future of medicine will be defined by how we translate information into action. Mayo Clinic

Platform is the realization of that goal—a digital-first extension of the Mayo Clinic mission to provide

hope and healing to every patient. By uniting the world's leading technology partners with the world's

best clinical data, we are building a foundation for the next century of healthcare.

Mayo Clinic Platform Digital Health & Startup Portfolio

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