McKesson Corporation’s Strategic Business Segment Portfolio — page 1

McKesson Corporation’s

Strategic Business Segment

Portfolio

McKESSON

A Comprehensive Analysis of Global Healthcare Distribution,

Specialty Oncology, and Prescription Technology Solutions

McKesson Corporation’s Strategic Business Segment Portfolio — page 2

McKesson Corporation’s Strategic Business Segment Portfolio — page 3

A V I G A T I O N

Portfolio Overview

Executive Overview

The McKesson Strategy: Advancing Health Outcomes

U.S. Pharmaceutical: The Distribution Backbone

Oncology and Multispecialty: Scaling Specialty Care

Prescription Technology Solutions (RxTS)

Medical-Surgical Solutions: Operational Excellence

Supply Chain & Global Infrastructure

Strategic Portfolio Optimization & M&A

The Oncology Ecosystem: Sarah Cannon & US Oncology

Digital Innovation & Medication Access

Financial Performance & Segment Revenue

Sustainability & Social Responsibility

Leadership & Corporate Governance

Future Outlook: 2027 & Beyond

Glossary and Methodology

STRATEGIC PORTFOLIO ANALYSIS

PAGE 02

McKesson Corporation’s Strategic Business Segment Portfolio — page 4

O R P O R A T E V I S I O N

Executive Overview

McKesson Corporation is a global leader in healthcare supply chain management solutions and retail

pharmacy. As a foundational pillar of the North American healthcare infrastructure, McKesson

ensures the seamless delivery of medicines, medical products, and healthcare technology to millions

of patients daily.

Streamlined Growth Strategy

The company is undergoing a multi-year transformation, divesting non-core

international assets and doubling down on high-growth, high-margin sectors:

Oncology, Biopharma Services, and Prescription Technology.

MCKESSON CORPORATION PORTFOLIO

PAGE 03

McKesson Corporation’s Strategic Business Segment Portfolio — page 5

O R E D I S T R I B U T I O N

U.S. Pharmaceutical

This segment represents the core engine of McKesson, managing the distribution of branded, generic,

specialty, and over-the-counter pharmaceuticals. It provides value-added services to retail pharmacies

and institutional providers.

40,000+

$250B+

Supply Chain Infrastructure

Utilizing a sophisticated, automated logistics network, McKesson maintains a "near-zero" error rate in

medication delivery, ensuring pharmaceutical manufacturers can reach every community in North

America with speed and security.

RETAIL PHARMACIES SERVED

ANNUAL SEGMENT REVENUE

PHARMACEUTICAL SUPPLY CHAIN

PAGE 04

McKesson Corporation’s Strategic Business Segment Portfolio — page 6

P E C I

A L T

Y C A R E F O C U S

Oncology and Multispecialty

McKesson has strategically positioned itself as the leader in community-based oncology. Through the

US Oncology Network and partnerships in clinical research, McKesson provides comprehensive

support to specialty practices.

The Sarah Cannon Joint Venture

The partnership with Sarah Cannon Research Institute (SCRI) expands

McKesson's clinical trial reach and data analytics capabilities, creating a unique

"bench-to-bedside" ecosystem.

Segment Highlights

The US Oncology Network:

Over 1,400 affiliated physicians in community practice.

Specialty Distribution:

Secure logistics for complex biologics and emerging therapies.

Ontada:

Data-driven insights to improve outcomes in oncology care.

•

SPECIALTY SEGMENT LEADERSHIP

PAGE 05

McKesson Corporation’s Strategic Business Segment Portfolio — page 7

O R T F O L I O D E

T A I L

Medical-Surgical Solutions: Operational

Excellence

This section provides a detailed analysis of the strategic initiatives within the Medical-Surgical

Solutions: Operational Excellence domain. McKesson's leadership continues to focus on operational

scale and financial performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 06

McKesson Corporation’s Strategic Business Segment Portfolio — page 8

O R T F O L I O D E

T A I L

Supply Chain & Global Infrastructure

This section provides a detailed analysis of the strategic initiatives within the Supply Chain & Global

Infrastructure domain. McKesson's leadership continues to focus on operational scale and financial

performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 07

McKesson Corporation’s Strategic Business Segment Portfolio — page 9

O R T F O L I O D E

T A I L

Strategic Portfolio Optimization & M&A

This section provides a detailed analysis of the strategic initiatives within the Strategic Portfolio

Optimization & M&A domain. McKesson's leadership continues to focus on operational scale and

financial performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 08

McKesson Corporation’s Strategic Business Segment Portfolio — page 10

O R T F O L I O D E

T A I L

The Oncology Ecosystem: Sarah Cannon

& US Oncology

This section provides a detailed analysis of the strategic initiatives within the The Oncology

Ecosystem: Sarah Cannon & US Oncology domain. McKesson's leadership continues to focus on

operational scale and financial performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 09

McKesson Corporation’s Strategic Business Segment Portfolio — page 11

O R T F O L I O D E

T A I L

Digital Innovation & Medication Access

This section provides a detailed analysis of the strategic initiatives within the Digital Innovation &

Medication Access domain. McKesson's leadership continues to focus on operational scale and

financial performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 10

McKesson Corporation’s Strategic Business Segment Portfolio — page 12

O R T F O L I O D E

T A I L

Financial Performance & Segment

Revenue

This section provides a detailed analysis of the strategic initiatives within the Financial Performance &

Segment Revenue domain. McKesson's leadership continues to focus on operational scale and

financial performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 11

McKesson Corporation’s Strategic Business Segment Portfolio — page 13

O R T F O L I O D E

T A I L

Sustainability & Social Responsibility

This section provides a detailed analysis of the strategic initiatives within the Sustainability & Social

Responsibility domain. McKesson's leadership continues to focus on operational scale and financial

performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 12

McKesson Corporation’s Strategic Business Segment Portfolio — page 14

O R T F O L I O D E

T A I L

Leadership & Corporate Governance

This section provides a detailed analysis of the strategic initiatives within the Leadership & Corporate

Governance domain. McKesson's leadership continues to focus on operational scale and financial

performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 13

McKesson Corporation’s Strategic Business Segment Portfolio — page 15

O R T F O L I O D E

T A I L

Future Outlook: 2027 & Beyond

This section provides a detailed analysis of the strategic initiatives within the Future Outlook: 2027 &

Beyond domain. McKesson's leadership continues to focus on operational scale and financial

performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 14

McKesson Corporation’s Strategic Business Segment Portfolio — page 16

O R T F O L I O D E

T A I L

Glossary and Methodology

This section provides a detailed analysis of the strategic initiatives within the Glossary and

Methodology domain. McKesson's leadership continues to focus on operational scale and financial

performance to drive shareholder value.

Strategic Imperative

Leveraging digital innovation to simplify the patient journey and reduce costs

across the healthcare ecosystem.

By integrating prescription technology and medical-surgical solutions, McKesson creates a

comprehensive platform that addresses the needs of modern healthcare providers in an increasingly

complex regulatory environment.

PAGE 15

McKesson Corporation’s Strategic Business Segment Portfolio

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