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Medicinal Sciences
Small Molecule Product & Process Development
n
Computational Product and Process Design (CPPD)
–
To complement and advance our experimentation
and manufacturing processes with computational tools,
including translating drug molecular structures to material
properties in silico. Some of the areas of interest include
in silico design & screening of synthetic pathways and
structure-based stability prediction.
n
Materials Sciences and Particle Engineering
–
Development of molecular structure-based particle design
and engineering tools that allow for the prediction and
manipulation of crystal form/morphology, solid-state
stability and material properties.
n
Portable, Continuous, Miniature and Modular
Development and Manufacturing Equipment
–
Design and development of fit-for-purpose, small footprint,
plug-and-play (modular) processing platforms, for drug
product and API that allow the same equipment to be
used for development and commercial manufacturing.
Desired state is for processing modules to be capable of
manufacturing multiple products at a wide range of scales
and enable significant reduction in scale-up and technology
transfer efforts.
n
Innovative Chemical Synthesis
–
Development of
new platform syntheses that include sustainable/“green”
chemical technologies and innovative chemical
transformations. Partnerships in the areas of replacement
of endangered metal catalysts and general methods for
catalytic preparation of chiral amines are desired.
n
Drug Delivery Technologies
–
Advanced drug delivery
technologies to enable differentiated therapies and the
next generation of precision medicine. Specific areas of
interest include:
–
Novel parenteral solubilization and delivery approaches
–
Membrane permeability-enhancing drug delivery
platforms
–
Differentiated pediatric dosage forms (ideally solids-
based) that mask, neutralize or improve taste without
affecting the pharmacokinetics for oral immediate-
release products
n
Advanced Analytical Technologies
–
Innovative
analytical platforms to enable real-time process
understanding and/or control via on-line or at-line
technology for Drug Product and API. Specific areas of
interest include:
–
Process Analytical Technologies (PAT) and sensor
technology for advanced process control
–
Microfluidic sample handling platforms compatible with
continuous manufacturing processes
–
Miniaturized, robust separation sciences platforms
–
3-D mapping/imaging of drug products
External Science & Innovation Contact:
Anthony Barry (anthony.b.barry@pfizer.com)
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